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JACKSONVILLE JAGUARS
SAN FRANCISCO 49ERS

Sunday, September 28 4:05 PM ET
LATEST ODDS
The 49ers are favorites to win against Jacksonville, in what is projected to be a 24.5 SF to 21.0 JAX game result.
LINE
SPREAD
O/U
+140
+3.5
45.5
-170
-3.5
45.5
ODDS OF WINNING
 JAX
SF 
60%
40%
IMPLIED TEAM TOTALS
Jacksonville
21.0 POINTS
24.5 POINTS
San Francisco
LAST 2 HEAD TO HEAD
San Francisco has won 2 of the last 2 games against Jacksonville.
DATE
SCORE
Nov 12, 2023
JAX 3 - SF 34
Nov 21, 2021
JAX 10 - SF 30
LAST 10 RESULTS
JAGUARS
49ERS
DATE
OPP
SCORE
Sep 28, 2025
@  SF
W 26 - 21
Sep 21, 2025
vs  HOU
W 17 - 10
Sep 14, 2025
@  CIN
L 27 - 31
Sep 7, 2025
vs  CAR
W 26 - 10
Jan 5, 2025
@  IND
L 23 - 26
Dec 29, 2024
vs  TEN
W 20 - 13
Dec 22, 2024
@  LV
L 14 - 19
Dec 15, 2024
vs  NYJ
L 25 - 32
Dec 8, 2024
@  TEN
W 10 - 6
Dec 1, 2024
vs  HOU
L 20 - 23
Sep 28, 2025
vs  JAX
L 21 - 26
Sep 21, 2025
vs  ARI
W 16 - 15
Sep 14, 2025
@  NO
W 26 - 21
Sep 7, 2025
@  SEA
W 17 - 13
Jan 5, 2025
@  ARI
L 24 - 47
Dec 30, 2024
vs  DET
L 34 - 40
Dec 22, 2024
@  MIA
L 17 - 29
Dec 12, 2024
vs  LAR
L 6 - 12
Dec 8, 2024
vs  CHI
W 38 - 13
Dec 1, 2024
@  BUF
L 10 - 35
OFFENSIVE MATCHUP EDGE
AVERAGE SCORE
JAX
SF
Last 5 Games
22.6
23.4
Last 10 Games
18.8
19.8
This Season
23.3
19.7
DEFENSIVE MATCHUP EDGE
AVG SCORE ALLOWED
JAX
SF
Last 5 Games
18.0
27.2
Last 10 Games
22.2
26.3
This Season
17.0
16.3