NFL
NBA
NHL
MLB
MORE:
My Account
DFF Premium
Contact Us

INDIANAPOLIS COLTS
SAN FRANCISCO 49ERS

Monday, December 22 8:15 PM ET
LATEST ODDS
The 49ers are favorites to win against Indianapolis, in what is projected to be a 25.5 SF to 20.0 IND game result.
LINE
SPREAD
O/U
+210
+5.5
45.5
-260
-5.5
45.5
ODDS OF WINNING
 IND
SF 
69%
31%
IMPLIED TEAM TOTALS
Indianapolis
20.0 POINTS
25.5 POINTS
San Francisco
LAST 1 HEAD TO HEAD
Indianapolis has won 1 of the last 1 games against San Francisco.
DATE
SCORE
Oct 24, 2021
IND 30 - SF 18
LAST 10 RESULTS
COLTS
49ERS
DATE
OPP
SCORE
Dec 14, 2025
@  SEA
L 16 - 18
Dec 7, 2025
@  JAX
L 19 - 36
Nov 30, 2025
vs  HOU
L 16 - 20
Nov 23, 2025
@  KC
L 20 - 23
Nov 9, 2025
vs  ATL
W 31 - 25
Nov 2, 2025
@  PIT
L 20 - 27
Oct 26, 2025
vs  TEN
W 38 - 14
Oct 19, 2025
@  LAC
W 38 - 24
Oct 12, 2025
vs  ARI
W 31 - 27
Oct 5, 2025
vs  LV
W 40 - 6
Dec 14, 2025
vs  TEN
W 37 - 24
Nov 30, 2025
@  CLE
W 26 - 8
Nov 24, 2025
vs  CAR
W 20 - 9
Nov 16, 2025
@  ARI
W 41 - 22
Nov 9, 2025
vs  LAR
L 26 - 42
Nov 2, 2025
@  NYG
W 34 - 24
Oct 26, 2025
@  HOU
L 15 - 26
Oct 19, 2025
vs  ATL
W 20 - 10
Oct 12, 2025
@  TB
L 19 - 30
Oct 2, 2025
@  LAR
W 26 - 23
OFFENSIVE MATCHUP EDGE
AVERAGE SCORE
IND
SF
Last 5 Games
20.4
30.0
Last 10 Games
26.9
26.4
This Season
28.0
24.6
DEFENSIVE MATCHUP EDGE
AVG SCORE ALLOWED
IND
SF
Last 5 Games
24.4
21.0
Last 10 Games
22.0
21.8
This Season
21.6
20.9