ARIZONA CARDINALS @
/ SAN FRANCISCO 49ERS

Sunday, September 27 4:05 PM ET · Levi's® Stadium

Levi's® Stadium

GAME STARTS IN

DAY

HOUR

MIN

SEC

LATEST ODDS

The 49ers are heavy favorites to win at home against Arizona, in what is projected to be a 28.0 SF to 20.5 ARI game result.

MONEYLINE

SPREAD

O/U

ARIZONA ARI 1 - 1

+310

+7.5

48.5

SAN FRANCISCO SF 2 - 0

-400

-7.5

48.5

ODDS OF WINNING

ARI

77%

23%

IMPLIED TEAM TOTALS

Arizona

20.5 POINTS

28.0 POINTS

San Francisco

LAST 6 HEAD TO HEAD

San Francisco has won 4 of the last 6 games against Arizona.

NOV 16, 2025

ARI 22 - SF 41

SPREAD

SF won against the spread

-3.5 SF

MONEYLINE

SF won straight up

-190 SF

TOTAL

The match went over 48.5 points

OVER 48.5

SEP 21, 2025

ARI 15 - SF 16

SPREAD

SF won against the spread

-1.5 SF

MONEYLINE

SF won straight up

-130 SF

TOTAL

The match went under 44.5 points

UNDER 44.5

JAN 5, 2025

ARI 47 - SF 24

SPREAD

ARI won against the spread

-4.5 ARI

MONEYLINE

ARI won straight up

-210 ARI

TOTAL

The match went over 42.5 points

OVER 42.5

OCT 6, 2024

ARI 24 - SF 23

SPREAD

ARI won against the spread

+7.5 ARI

MONEYLINE

ARI won straight up

+260 ARI

TOTAL

The match went under 49.5 points

UNDER 49.5

DEC 17, 2023

ARI 29 - SF 45

SPREAD

SF won against the spread

-12.5 SF

MONEYLINE

SF won straight up

-625 SF

TOTAL

The match went over 49.0 points

OVER 49.0

OCT 1, 2023

ARI 16 - SF 35

SPREAD

SF won against the spread

-14.0 SF

MONEYLINE

SF won straight up

-1000 SF

TOTAL

The match went over 43.5 points

OVER 43.5

DATE

SCORE

MONEY

SPREAD

OVER/UNDER

WINNER

Nov 16, 2025

ARI 22 - SF 41

-190 SF

-3.5 SF

48.5 Over

WIN BY 19

Sep 21, 2025

ARI 15 - SF 16

-130 SF

-1.5 SF

44.5 Under

WIN BY 1

Jan 5, 2025

ARI 47 - SF 24

-210 ARI

-4.5 ARI

42.5 Over

WIN BY 23

Oct 6, 2024

ARI 24 - SF 23

+260 ARI

+7.5 ARI

49.5 Under

WIN BY 1

Dec 17, 2023

ARI 29 - SF 45

-625 SF

-12.5 SF

49.0 Over

WIN BY 16

Oct 1, 2023

ARI 16 - SF 35

-1000 SF

-14.0 SF

43.5 Over

WIN BY 19

LAST 10 RESULTS

CARDINALS

49ERS

DATE

OPP

SCORE

MONEY

SPREAD

OVER/UNDERO/U

Sep 20, 2026

SEA

L 7 - 31

L +175

L +3.5

40.5 Under

Sep 13, 2026

LAC

W 26 - 14

W +450

W +10.5

45.5 Under

Jan 4, 2026

LAR

L 20 - 37

L +800

L +14.5

47.5 Over

Dec 28, 2025

CIN

L 14 - 37

L +260

L +7.5

53.5 Under

Dec 21, 2025

ATL

L 19 - 26

L +130

L +2.5

48.5 Under

Dec 14, 2025

HOU

L 20 - 40

L +425

L +10.5

42.5 Over

Dec 7, 2025

LAR

L 17 - 45

L +375

L +9.5

48.5 Over

Nov 30, 2025

L 17 - 20

L +160

L +3.5

44.5 Under

Nov 23, 2025

JAX

L 24 - 27

L +115

L +2.5

47.5 Over

Nov 16, 2025

L 22 - 41

L +160

L +3.5

48.5 Over

Sep 20, 2026

MIA

W 35 - 13

W -1000

W -13.5

44.5 Over

Sep 10, 2026

LAR

W 27 - 7

W +165

W +3.5

48.5 Under

Jan 17, 2026

SEA

L 6 - 41

L +240

L +7.5

44.5 Over

Jan 11, 2026

PHI

W 23 - 19

W +210

W +5.5

43.5 Under

Jan 3, 2026

SEA

L 3 - 13

L +120

L +2.5

48.5 Under

Dec 28, 2025

CHI

W 42 - 38

W -190

W -3.5

51.5 Over

Dec 22, 2025

IND

W 48 - 27

W -225

W -4.5

46.5 Over

Dec 14, 2025

TEN

W 37 - 24

W -899

W -12.5

44.5 Over

Nov 30, 2025

CLE

W 26 - 8

W -250

W -5.5

35.5 Under

Nov 24, 2025

CAR

W 20 - 9

W -400

W -7.5

49.5 Under

OFFENSIVE MATCHUP EDGE

AVERAGE SCORE

ARI

Last 5 Games

17.2

18.8

Last 10 Games

18.6

26.7

This Season

16.5

31.0

DEFENSIVE MATCHUP EDGE

AVG SCORE ALLOWED

ARI

Last 5 Games

29.0

18.6

Last 10 Games

31.8

19.9

This Season

22.5

10.0

ARIZONA CARDINALS @ / SAN FRANCISCO 49ERS

ARIZONA CARDINALS @
/ SAN FRANCISCO 49ERS