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ARIZONA CARDINALS
SAN FRANCISCO 49ERS

Sunday, September 21 4:25 PM ET
LATEST ODDS
The 49ers are slightly favored to win against the Arizona Cardinals, in what is projected to be a 23.0 SF to 21.5 ARI game result.
LINE
SPREAD
O/U
+110
+1.5
44.5
-130
-1.5
44.5
ODDS OF WINNING
 ARI
SF 
54%
46%
IMPLIED TEAM TOTALS
Arizona
21.5 POINTS
23.0 POINTS
San Francisco
LAST 6 HEAD TO HEAD
San Francisco has won 4 of the last 6 games against Arizona.
DATE
SCORE
Jan 5, 2025
ARI 47 - SF 24
Oct 6, 2024
ARI 24 - SF 23
Dec 17, 2023
ARI 29 - SF 45
Oct 1, 2023
ARI 16 - SF 35
Jan 8, 2023
ARI 13 - SF 38
Nov 21, 2022
ARI 10 - SF 38
LAST 10 RESULTS
CARDINALS
49ERS
DATE
OPP
SCORE
Sep 14, 2025
vs  CAR
W 27 - 22
Sep 7, 2025
@  NO
W 20 - 13
Jan 5, 2025
vs  SF
W 47 - 24
Dec 22, 2024
@  CAR
L 30 - 36
Dec 15, 2024
vs  NE
W 30 - 17
Dec 8, 2024
vs  SEA
L 18 - 30
Dec 1, 2024
@  MIN
L 22 - 23
Nov 24, 2024
@  SEA
L 6 - 16
Nov 10, 2024
vs  NYJ
W 31 - 6
Nov 3, 2024
vs  CHI
W 29 - 9
Sep 14, 2025
@  NO
W 26 - 21
Sep 7, 2025
@  SEA
W 17 - 13
Jan 5, 2025
@  ARI
L 24 - 47
Dec 30, 2024
vs  DET
L 34 - 40
Dec 22, 2024
@  MIA
L 17 - 29
Dec 12, 2024
vs  LAR
L 6 - 12
Dec 8, 2024
vs  CHI
W 38 - 13
Dec 1, 2024
@  BUF
L 10 - 35
Nov 24, 2024
@  GB
L 10 - 38
Nov 17, 2024
vs  SEA
L 17 - 20
OFFENSIVE MATCHUP EDGE
AVERAGE SCORE
ARI
SF
Last 5 Games
30.8
23.6
Last 10 Games
26.0
19.9
This Season
23.5
21.5
DEFENSIVE MATCHUP EDGE
AVG SCORE ALLOWED
ARI
SF
Last 5 Games
22.4
30.0
Last 10 Games
19.6
26.8
This Season
17.5
17.0